CINCINNATI (AP)Joe Burrow threw two touchdown passes and ran for another score, Samaje Perine rushed for a season-high 106 yards and the Cincinnati Bengals beat the Kansas City Chiefs 27-24 on Sunday in their first meeting since the Bengals prevailed in last season’s AFC championship game.

Patrick Mahomes and Chiefs lost their chance to avenge two losses to Burrow and Cincinnati last season. The Bengals beat the Chiefs last Jan. 2 to clinch the AFC North title, then won four weeks later in overtime to reach the Super Bowl for the first time in 33 years.

With the Chiefs leading 24-20, Cincinnati linebacker Germaine Pratt stripped Trave Kelce after a catch and recovered the fumble.

Burrow, working from his own 47, then completed six of seven passes for 53 yards, finishing the drive with an 8-yard TD pass to backup running back Chris Evans that gave the Bengals the lead with 8:54 remaining.

The subsequent Chiefs drive was snuffed out when Joseph Ossai sacked Mahomes, and Harrison Butker missed a 55-yard field-goal attempt wide right.

Burrow finished 25 for 31 for 286 yards. Ja’Marr Chase, in his return after missing four games with a hip injury, had seven receptions for 97 yards.

Mahomes was 16 for 27 for 223 yards and a touchdown and ran for another score.

COWBOYS 54, COLTS 19

ARLINGTON, Texas (AP) – Malik Hooker returned a fumble 38 yards for a touchdown against his former team and Dallas scored 33 points in the fourth quarter to rout Indianapolis.

Dallas led 21-19 entering the fourth when Dak Prescott threw the last of his three touchdown passes. Hooker’s scoop-and-score was the first of four fourth-quarter takeaways by Dallas, all of which led to touchdowns.

The highest-scoring quarter for the Cowboys (9-3) since at least 1991 was just the third time in NFL history a team scored as many as 33 points in the fourth.

Matt Ryan threw his second and third interceptions and lost a fumble during the nightmare finish for the Colts (4-8-1), who fell to 1-3 under interim coach Jeff Saturday and lost for the sixth time in seven games overall.

Ryan, who threw two touchdown passes, has 18 giveaways this season (13 interceptions, five lost fumbles) to lead the NFL by three over Buffalo quarterback Josh Allen.

Michael Gallup had two touchdown catches and CeeDee Lamb the other for the Cowboys, who remained two games behind NFL-leading Philadelphia in the NFC East.

49ERS 33, DOLPHINS 17

SANTA CLARA, Calif. (AP) – Rookie Brock Purdy threw two touchdown passes after replacing Jimmy Garoppolo – who suffered a broken left foot that will end his season – and San Francisco used another dominant defensive performance to beat Miami for its fifth straight win.

The 49ers (8-4) allowed a 75-yard touchdown pass to Trent Sherfield on the opening play from scrimmage but little else until the fourth quarter against a high-powered attack for Miami (8-4) that had scored at least 30 points in four straight games.

Jimmie Ward and Deommodore Lenoir intercepted Tua Tagovailoa in the third quarter, leading to two field goals.

Tagovailoa threw a 45-yard TD pass to Tyreek Hill in the opening minute of the fourth quarter, but the Niners held on from there. They capped the performance with a strip-sack from Nick Bosa that Dre Greenlaw returned for a 23-yard score.

The Dolphins had their five-game winning streak snapped in coach Mike McDaniel’s first game against the 49ers after spending the past five years as an assistant in San Francisco.

Garoppolo hurt his foot on a sack on the final play of the opening drive. Purdy capped his first drive of the game by throwing a 3-yard TD pass to Kyle Juszczyk to give San Francisco a 10-7 lead.

He then led a well-executed two-minute drive at the end of the half, completing six passes for 75 yards with a 3-yard TD to Christian McCaffrey with 4 seconds left in the half to make it 17-10.

Purdy finished 25 for 37 for 210 yards, two TDs and one interception.

COMMANDERS 20, GIANTS 20, OT

EAST RUTHERFORD, N.J. (AP) – Graham Gano came up well short on a 58-yard field goal attempt on the last play of overtime, and New York and Washington tied.

Taylor Heinicke threw two touchdown passes for Washington and converted a crucial fourth-down pass during a tying 90-yard touchdown drive late in the fourth quarter.

The Giants (7-4-1) ended a two-game losing streak, while the Commanders (7-5-1) are unbeaten in four (3-0-1) and have only one loss in their last eight games.

Heinicke was 27 of 41 for 275 yards and threw touchdown passes of 19 yards to Terry McLaurin (8 catches, 105 yards) and 28 yards to Jahan Dotson that tied it with 1:45 to play. That drive featured Heinicke rolling to his left to hit Curtis Samuel for 20 yards on a fourth-and-4 play from his own 27 with less than three minutes to play.

Daniel Jones threw a 6-yard touchdown pass to Isaiah Hodgins, and Saquon Barkley scored on a 13-yard run. Gano kicked two field goals for the Giants.

New York’s defense set up Hodgins’ first NFL touchdown early in the second half for a 20-13 lead. Azeez Ojulari sacked Heinicke and forced a fumble. Oshane Ximines recovered but also fumbled, and Ojulari ultimately collected the ball at the Washington 20.

RAVENS 10, BRONCOS 9

BALTIMORE (AP) – Tyler Huntley capped a 91-yard drive with a 2-yard touchdown run with 28 seconds remaining, and Baltimore overcame Lamar Jackson’s injury to beat Denver.

Jackson left after the first quarter with an injured knee, and the Broncos mostly shut down Baltimore after that. But on their final possession, the Ravens drove 16 plays, aided by a couple big Denver penalties. Huntley converted on fourth-and-2 from the Denver 18 with a short run, then Kenyan Drake caught a 13-yard pass.

Huntley scored on the next play for the Ravens (8-4), who stayed atop the AFC North.

Russell Wilson led the Broncos (3-9) back into Baltimore territory, but Brandon McManus came up short on a 63-yard field goal as time expired.

Denver’s offense couldn’t shake out of its season-long funk, and three field goals by McManus weren’t enough. The Broncos have lost four straight, scoring only 45 points in that span.

Jackson left after being sacked by Jonathon Cooper on the last play of the first quarter. The 2019 MVP exited the sideline tent, walked to the tunnel and didn’t return. Huntley went 27 of 32 for 187 yards with an interception.

VIKINGS 27, JETS 22

MINNEAPOLIS (AP) – Justin Jefferson’s touchdown catch with 8:33 left gave Minnesota enough of a lead to hang on despite a relentless rally by New York.

Camryn Bynum’s interception at the 1-yard line with 10 seconds left finally sealed it for the Vikings (10-2), who completed a four-game sweep of the AFC East in their typical nail-biting fashion.

Mike White, who was picked off twice, was 31 of 57 for 369 yards in his second start this season for the Jets (7-5). He scored on a fourth-and-goal sneak from the 1 to pull within five points with 6:45 to go.

With 1:43 remaining, White’s fourth-and-goal pass from the 1 was incomplete when Braxton Berrios bobbled it and the ball hit the turf. The Jets had all three timeouts left and got the ball back at the Minnesota 43, but with White under plenty of pressure they stalled out at the 19.

Dalvin Cook and Alexander Mattison rushed for first-half touchdowns and Greg Joseph made two field goals for the Vikings, who took a 20-3 lead late in the second quarter.

But Minnesota netted 10 yards on three third-quarter possessions and ended up in its ninth one-score game of the season. The Vikings missed some crucial tackles and allowed three plays of 30-plus yards in the final 15 minutes to aid the rally.

BROWNS 27, TEXANS 14

HOUSTON (AP) – Deshaun Watson had a sloppy performance in his first game in 700 days, but a punt return for a touchdown by Donovan Peoples-Jones and two defensive TDs were enough for Cleveland to beat lowly Houston.

In the same stadium where he played his previous game, a rusty Watson threw for 131 yards with an interception in his debut for the Browns (5-7) against his former team in his return after serving an 11-game NFL suspension for sexual misconduct allegations.

The Browns trailed 5-0 early but a 76-yard punt return by Peoples-Jones put them on top in the second quarter and Denzel Ward’s 4-yard fumble return for a score pushed the lead to 14-5 early in the third quarter.

Cleveland didn’t score on offense until a 43-yard field goal made it 17-8 with about 10 minutes remaining. The Browns added a second defensive score when Tony Fields intercepted Kyle Allen and returned it 16 yards on the next play. The Texans (1-10-1) lost their seventh straight.

Allen had a terrible day in his second start since Davis Mills was benched. He threw for 201 yards with a fumble that was returned for a touchdown and two interceptions.

Watson was 12 of 22 and finished with a 53.4 QB rating, the lowest of his career.

EAGLES 35, TITANS 10

PHILADELPHIA (AP) – Jalen Hurts strengthened his MVP bid by throwing for 380 yards and three touchdowns and running for another score, and A.J Brown caught two touchdown passes against his former team as Philadelphia beat Tennessee.

Hurts has led the Eagles to an 11-1 start, their first time with that record since 2004 and the fourth time in franchise history. The 1949 Eagles won the NFL championship. The 1980 and 2004 teams lost in the Super Bowl.

The speedy, sure-armed QB set a career high with 29 total touchdowns and had his third career game with four total TDs. His first half alone was a pretty good game for most quarterbacks: 268 yards passing and two touchdowns with one rushing score.

The Eagles’ defense was first-rate, too, bottling up Derrick Henry – who had 11 carries for 30 yards – and limiting Ryan Tannehill to 141 yards passing and a touchdown. The Titans (7-5) lost their second straight but still have a comfortable lead in the AFC South.

After a field goal got Tennessee within 14-10 late in the second quarter, the Titans punted on five straight possessions before turning it over on downs.

Brown had eight catches for 119 yards. Teammate DeVonta Smith had five catches for 102 yards.

PACKERS 28, BEARS 19

CHICAGO (AP) – Aaron Rodgers led three fourth-quarter scoring drives, receiver Christian Watson took an end-around 46 yards for a touchdown in the closing minutes, and Green Bay rallied to beat Chicago.

The Packers (5-8) looked like they were on their way to another loss after dropping seven of eight, trailing 19-10 through three quarters. But they made enough plays down the stretch to come away with their eighth straight win over the Bears (3-10), who lost their sixth straight.

AJ Dillon ran for a 21-yard touchdown in the opening minute of the fourth and Mason Crosby kicked a 32-yard field goal to give Green Bay a 20-19 lead with just under five minutes left.

The Bears drove to the Packers 33 before Jaire Alexander stepped in front of Justin Fields’ pass intended for Equanimeous St. Brown and picked it off. Three plays later, Watson sprinted untouched to the end zone, and Rodgers completed a 2-point conversion pass to Mercedes Lewis. That made it 28-19 with 1:51 remaining.

Rodgers improved to 25-5 against Chicago counting the playoffs. The four-time MVP completed 18 of 31 passes for 182 yards and a touchdown.

Fields had a 55-yard touchdown run and finished with 71 rushing yards on six attempts, his sixth straight game with at least 50 rushing yards and a TD. He was 20 of 25 passing for 254 yards but threw two interceptions.

SEAHAWKS 27, RAMS 23

INGLEWOOD, Calif. (AP) – DK Metcalf caught an 8-yard touchdown pass from Geno Smith with 36 seconds to play, and Seattle overcame an inspired performance by Bobby Wagner to beat spiraling Los Angeles.

Smith passed for a career-high 367 yards and threw three TD passes for the Seahawks (7-5), who barely snapped their two-game skid with 438 yards of offense against a Rams defense missing Aaron Donald.

After Cam Akers’ second TD run put the Rams up 23-20 with 2:56 to play, Smith patiently directed the winning 75-yard drive, hitting Marquise Goodwin for 17 yards one play before finding Metcalf between defenders in the end zone.

Tyler Lockett and Noah Fant caught early TD passes from Smith in the most prolific game of the quarterback’s decade in the NFL. Metcalf had eight catches for 127 yards, and Lockett had nine receptions for a season-high 128 yards as the Seahawks sent defending Super Bowl champion Los Angeles (3-9) to its sixth straight defeat.

Wagner had two sacks and an interception for the Rams in his first career game against Seattle, where he spent the previous 10 years and made six All-Pro teams.

John Wolford passed for 178 yards with two interceptions for the Rams, who are ensured their first losing season in coach Sean McVay’s six-year tenure.

RAIDERS 27, CHARGERS 20

LAS VEGAS (AP) – Derek Carr completed two long touchdown passes to Davante Adams in the third quarter to rally Las Vegas past Los Angeles.

Josh Jacobs rushed for 144 yards and a touchdown, and the Raiders (5-7) improved to 5-1 when he has 100 or more yards. Jacobs has 1,303 yards this season, the most in Raiders history through 12 games.

Las Vegas sacked Justin Herbert five times, won its third straight and split its season series with the Chargers (6-6).

Los Angeles led 10-0 in the second quarter but the Raiders dominated from there. Carr completed a 31-yarder to Adams early in the third quarter to give Las Vegas the lead for good at 17-13. Less than four minutes later, the duo hooked up on a 45-yard flea flicker for another score.

Adams finished with eight receptions for 177 yards, surpassing 1,000 yards for the fourth time since 2018. Carr completed 16 of 30 passes for 250 yards.

Herbert completed 28 of 47 passes for 335 yards, his 20th career 300-yard game.

LIONS 40, JAGUARS 14

DETROIT (AP) – Jamaal Williams ran for his 14th touchdown this season and Detroit routed Jacksonville.

The Lions (5-7) scored on all five of their drives in the first half to take a 17-point lead, and then on their first three possessions of the second half to pull away.

The Jaguars (4-8) had a scare on the last play of the second quarter when quarterback Trevor Lawrence was sacked and grabbed his left knee, but their defense made his return moot.

Lawrence was taken out in the fourth quarter with his team trailing by 26 points. He finished 17 of 31 for 179 yards with a touchdown.

Detroit’s Jared Goff completed 31 of 41 passes for 340 yards and two touchdowns.

Amon-Ra St. Brown had 11 receptions for 114 yards and two touchdowns. D’Andre Swift rushed for 62 yards and a touchdown for the Lions.

STEELERS 19, FALCONS 16

ATLANTA (AP) – Kenny Pickett tossed a 17-yard touchdown pass to Connor Heyward, Matthew Wright kicked four field goals and Pittsburgh held off Atlanta.

Coming off a Monday night victory at Indianapolis, the Steelers (5-7) won two straight games for the first time during what’s been a tough rebuilding year.

The Falcons (5-8) had first-and goal from the Steelers 10 with a chance for a go-ahead touchdown. But a holding penalty on Parker Hesse wiped out Cordarrelle Patterson’s apparent TD run around left end, and the Falcons wound up settling for Younghoe Koo’s third field goal of the day from 28 yards with 5:27 remaining.

The Steelers ran off all but the final 42 seconds before Pressley Harvin pinned a punt at the Falcons 2-yard line. In desperation mode with no timeouts remaining, Marcus Mariota’s pass was picked off by Minkah Fitzpatrick to seal it.

Pickett’s touchdown pass to Heyward came midway through the second quarter, set up by a 57-yard completion to Pat Freiermiuth.

Wright connected from 46, 46, 48 and 38 yards. Pickett threw for 197 yards without an interception, and Najee Harris had 86 yards rushing.

AP NFL: https://apnews.com/hub/nfl and https://twitter.com/AP-NFL